Thus, this pathway appears to be relevant to the . Autophagy genes. Autophagy is activated when cells undergo stresses such as endoplasmic reticulum stress and nutrient deprivation ( 9 ). Interestingly, RANKL stimulation significantly increased autophagosome . Desirable but not required . 2019 Impact Factors Released for APS Journals. Long noncoding RNA BCRP3 stimulates VPS34 and autophagy activities to promote protein homeostasis and cell survival. They also observed that TMEM41B and the well-characterized early-stage autophagy protein VMP1 (top scoring HDF in our HCoV-229E screen with p-value = 3.1525e-08 and rank = 2; p-value = 3.4752e-02 and rank = 1919 for MERS-CoV) implement related functions [28-30]. Introduction. (F) Ranking of genes from the CRISPR/Cas9 screen based on the RRA (Robust Ranking Aggregation) algorithm score calculated using the MAGeCK method. A knock-in mutation in Beclin 1 (Becn1 F121A) ( 20) that results in increased basal autophagy decreases mammary tumorigenesis in mice with mammary-specific expression of HER2 and blocks HER2-mediated suppression of autophagy. There are relatively little data available on the role of autophagy markers in pathogenicity of breast cancer in the Iraqi population. Article Citations. The size of the glass cover slip depends on the number of sections present on a slide and the distance between the sections. We first asked whether TNF or TLR ligands promote cell death in autophagy-deficient macrophages by deleting Atg16l1, a core gene in the autophagy pathway. Molecular Cell Biology (impact factor: 94.444) Abstract Although the use of aspirin has substantially reduced the risks of cardiovascular events and death, its potential mechanisms have not been fully elucidated. Methods There are both constitutive and stress-induced pathways for autophagy in neurons, which catalyze the turnover of aged or damaged mitochondria, endoplasmic . It considers the number of citations received by a journal and the importance of the journals from where these citations come. Thus, we aim to study the effect of vanillic acid alone and along with . Autophagy is involved in both tumorigenesis and tumour suppression. Authors: Ruei-Liang Yan, Chiu-Lin Luan, Chun-Chieh Liao, Li-Heng Liu, . His Autophagy research is under the purview of Apoptosis. Vanillic acid is a naturally occurring polyphenol with promising therapeutic effects. CiteScore Rank. Among these genes, 6 genes were down-regulated and 24 were up-regulated in the tumor group compared with normal group (Table 1 ). Autophagy is an orderly catabolic process for degrading and removing unnecessary or dysfunctional cellular components such as proteins and organelles. KM analysis revealed significant survival differences in the two groups (log rank P < 0.0001, HR = 2.72, and 95% CI : 1.77-4.16, Figure 2(g) . (3years) Citable Docs. Article. Further experiments showed that narciclasine promoted the levels of autophagy proteins LC3-II, Atg-5 and Beclin-1, reduced the expression of the autophagy transporter p62, and increased autophagic flux. Introduction. Ranked by three separate measures Citations, Papers , and Citations Per Paper. All rankings have a 5 paper threshold for all measures. Design: Murine model of endotoxemia and cecal ligation and puncture (CLP) induced . Journal of Neuropathology and Experimental Neurology (2005) 1354 Citations Autophagy: in sickness and in health . Autophagy has emerged as a key player in metabolic disturbances, involved in adipocyte differentiation and adipogenesis, enhancing fat accumulation in the fat depots, with the potential of playing an important . Paired samples of tumor and adjacent non-malignant tissue were collected from 20 patients with ccRCC after radical nephrectomy. ISSN 1554-8627 Key Factor Analysis ISSN (Online) - Key Factor Analysis Publisher Landes Bioscience Key Factor Analysis Publication Frequency - Exercise is well known to be an effective tool against obesity and its consequences. The resulting database contained 738 journals. ISSN: 1689 . EMBO Press is a foundation signatory of the San Francisco Declaration on Research Assessment pointing to flaws in the Journal Impact Factor and particular in its application to the assessment of the research output of individuals.Please read this editorial for a more detailed discussion [The EMBO Journal (2015) 34 . The ranking h-index is inferred from publications deemed to belong to the considered discipline. The ranking h-index is inferred from publications deemed to belong to the considered discipline. Moreover, AMPK activation is clearly associated with etoposide-induced autophagy. . Ji et al. A track record of first-author publications in high-ranking peer-reviewed journals. between LC3 dot surface and peIF2α fluorescence intensity was calculated employing Spearman's rank test. In the present study, we aimed to determine the protective effects of aspirin on human coronary artery endothelial cells (HCAECs) and explore its underlying . 12,35 Many studies have shown that proper upregulation of autophagy could slow down aging and lengthen life span. Ana Maria Cuervo mostly deals with Autophagy, Cell biology, Chaperone-mediated autophagy, Lysosome and Intracellular. By using the autophagy inhibitors 3-MA and CQ, it was shown that narciclasine could induce autophagy-mediated apoptosis in gastric cancer cells. Autophagy. Finish mounting quickly within 30 s?1 min. ERβ-evoked CyclinD1 depletion and anti-proliferation are correlated with activated autophagy in HCT116 cells. Abstract Background and aims The prevalence of non-alcoholic fatty liver disease has been alarmingly increased with no lines of effective treatment. Oral metformin intervention improves T cell autophagy in people, indicating potential use for age-associated inflammation. 2018; 68 (6):394-424. doi: 10 . Autophagy is a cell cycle process that has emerged as a crucial mechanism for life span extension in many different species. Journal Abbreviation: AUTOPHAGY Journal ISSN: 1554-8627. The overall rank of Autophagy is 400 . This ranking lists all top researchers from the Biology and Biochemistry discipline and affiliated with Augusta University. Daolin Tang focuses on Autophagy, Cell biology, Programmed cell death, Cancer research and HMGB1. Volume 135, Journal of Cell Science publishes cutting-edge science, encompassing all aspects of cell biology. Nature Reviews. Articles. The mRNA levels of apoptosis ( BAD , BAX , BCL2 , BCLXL , BIM ) and autophagy ( ATG4 , BECN1 , GABARAP , p62 , UVRAG . As per available reports about 75 journals, 550 Conferences, 700 workshops are presently dedicated exclusively to Case Report and about 6,20000 articl. About Coverage Algorithms FAQ. Autophagy - July 2009. His Cell biology research includes . . You . H-Index. show that the autophagy proteins VMP1 and TMEM41B are required for β-coronavirus infection, and . RANK Ligand Modulation of Autophagy in Oral Squamous Cell Carcinoma Tumor Cells. The journal is free to publish in, while offering open-access options. Autophagy is well known as an evolutionarily conserved mechanism in eukaryotic cells for bulk degradation and recycling of cytoplasmic components (Zhuang et al., 2017; Zhuang et al., 2018).In plants, the autophagy process is initiated by the formation of the autophagosome, which engulfs and consumes cytoplasmic contents and ultimately fuses with the vacuole for macromolecule and . Autophagy is the major cellular pathway to degrade dysfunctional organelles and protein aggregates. substrate preparation in Note 25). (log rank , HR = 2.72, and 95% CI : 1.77-4.16, . . Objective: To determine that 1) an age-dependent loss of inducible autophagy underlies the failure to recover from AKI in older, adult animals during endotoxemia, and 2) pharmacologic induction of autophagy, even after established endotoxemia, is of therapeutic utility in facilitating renal recovery in aged mice. The FEBS Journal. Only Open Access Journals Only SciELO Journals Only WoS Journals. Its other most cited research outputs are Bosquet et . Publisher of over 50 scientific journals across the life, physical, earth, and health sciences, both independently and in partnership with scientific societies including Cell, Neuron, Immunity, Current Biology, AJHG, and the Trends Journals. Table 1. The FEBS Journal is a multidisciplinary, non-profit society journal that publishes full-length high-quality papers and expert reviews relevant to the molecular, cellular and biochemical life sciences. In our Special Topics analysis on autophagy, the journal ranks at #1 by total number of papers and #4 by total cites among journals publishing on the topic over the past decade. . Most Published Authors. Stimulation with TNF or TLR ligands does not significantly induce death of wild-type macrophages, with the exception of TLR3 which can drive caspase-8 mediated apoptosis via TRIF (Kaiser et al., 2013; Gentle et al., 2017; Kawasaki and Kawai . Our study screened for autophagy-related lncRNAs in 80 samples downloaded from The Cancer Genome Atlas (TCGA) database through lncRNA-mRNA coexpression. siRNA-mediated impairment of autophagy, but not mitophagy, in cells from younger subjects compromised mitochondrial function and activated a Th17 . 1.407 - SCImago Journal Rank (SJR) Usage 267,225 downloads (2021) 67 Altmetric mentions. Journal of Cell Biology (JCB) publishes advances in any area of basic cell biology as well as applied cellular advances in fields such as immunology, neurobiology, metabolism, microbiology, developmental biology, and plant biology. Source dates: 1999-February 28, 2009 (first bimonthly period 2009). The Journal of Bone and Joint Surgery. Journal Impact. Journal of Biomedical Science . Citable Docs. The Society for Investigative Dermatology (SID) advances science relevant to skin health and disease through education, advocacy, and scholarly exchange of scientific information. Cancer. SCImago Journal Rank (SJR) Usage 1,573,025 Downloads (2021) 302 Altmetrics mentions. Autophagy is a programmed cell degradation mechanism that has been associated with several physiological and pathophysiological processes, including malignancy. The process of degrading foreign microbial invaders by autophagy is known as xenophagy ( Levine, 2005 ). Issue 1. . Genes known to participate in autophagy are labeled in red; MAP1LC3B genes (i.e., LC3B and LC3B2) are labeled in black; a gene not previously implicated in autophagy, UBA6, is labeled in green. Journal of Cellular Biochemistry . Journal of Cell Biology (2010) 801 Citations . Display journals with at least. Apoptosis. Journal of Neuropathology and Experimental Neurology (2005) 1354 Citations Autophagy: in sickness and in health . The following list highlights some recent SRP-funded publications in high impact journals. Univariate Cox regression analysis of overall survival (OS) was performed to identify risk-associated . Background Autophagy is a cellular pathway that regulates transportation of cytoplasmic macromolecules and organelles to lysosomes for degradation. SJR : Scientific Journal Rankings. Citations. Calorie Restriction Mimetics - Rapamycin and metformin mimic the effects of fasting by suppressing mTOR and insulin. SCImago Journal Rank is an indicator, which measures the scientific influence of journals. OA induced autophagy and apoptosis mainly in an AMPK activation-dependent manner in CC cells. from submission to first decision Top 20 Overall: Authors | Institutions | Journals | Nations. When cells are under stress such as starvation, autophagy is elevated to redistribute energy to sustain cell survival; however, it could also lead to cell death when the attempts to sustain viability have failed (). Autophagy: From the Bench to the Bedside, Basic Science Translated; Basic Science and Disease Mechanisms in Multiple Organ Systems; The nonlytic route of viral spread proposed, a form of unconventional secretion, would result in the release of a few virus particles from a living cell, either from intact or ruptured inner compartments of autophagosome-like vesicles induced during infection. 2021, Article ID 8281718, 17 pages, 2021. https: . Scopus awards the impact factor. Abstract. Knockdown of autophagy in T cells from young subjects activates this profile. In vitro metformin improves autophagy and mitochondrial function in parallel to ameliorate Th17 inflammaging. Autophagy is an evolutionally highly conserved process, accompanied by the dynamic changes of various molecules, which is necessary for the orderly degradation and recycling of cellular components. 1 - 50 of 12410. ANC is sister journal to Acta Neuropathologica, a journal dedicated to the pathology and mechanisms of neurological disease. Autophagy is an essential cellular pathway involved in homeostasis maintenance through degradation and recycling of almost every cellular component, from proteins to lipids and organelles in lysosomes [].Three main types of autophagy coexist in most mammalian cells: macroautophagy, chaperone-mediated autophagy (CMA), and microautophagy []. Rankings of Autophagy based on publications and citations in various years. Metabolic syndrome is a condition that involves disruption of energy homeostasis in several organs and tissues, such as adipose tissue, liver, and pancreas including the immune system. Deep Autophagy - This is rank one because of ramping up autophagy more severely and causing extra energy stress. We examined the status and role of autophagy, a process of lysosomal recycling of cellular material, in clear cell renal cell carcinoma (ccRCC). In apoptosis-defective cells, the induction of autophagy has been commonly charged with anticancer therapies in multiple kinds of cancers and shown to elicit an effect on tumor growth inhibition [].When autophagy occurs, the soluble LC3-I is converted to LC3-II, and LC3-II then . Autophagy, Cell biology, Gene knockdown, BAG3 and Programmed cell death are his primary areas of study. Pink cytoplasm indicates infection by PV-DsRed virus. Sheldon Goldberg. Currently, no autophagy-related long noncoding RNA (lncRNA) has been reported to predict the prognosis of uveal melanoma patients. Although autophagy is known to play an important role in various types of cancer, the effects of autophagy-related genes (ARGs) on colon cancer have not been well studied. OSCC cells express high levels of RANK ligand (RANKL); however, a functional . Protective effects of dexmedetomidine in vital organ injury: crucial roles of autophagy. Expression profiles from ARGs in 457 colon cancer patients were retrieved . Autophagy is particularly important in neurons, which are terminally differentiated cells that must last the lifetime of the organism. ISSN: 2051-5960. Key personal characteristics Ana Maria Cuervo mostly deals with Autophagy, Cell biology, Chaperone-mediated autophagy, Lysosome and Intracellular. Most Cited Authors. Subject Area Rank Percentile; Category: Biochemistry, Genetics and Molecular Biology Subcategory: Molecular Biology: 28 / 382: Clarivate Analytics has released its 2020 edition of the Journal Citation Reports, which gives journal impact factors and rankings of more than 11,000 scholarly journals.The 2019 impact factors of APS journals, along with a comparison of the past two years, are given in the table below. A Cancer Journal for Clinicians. Citation Distribution Read more about our Aims and Scope here. Cyrus Vahdatpour, David Collins and. Yuvaraj Sambandam. Autophagy Impact Factor, IF, number of article, detailed information and journal factor. Minimal 4 years of prior research experience at a Ph.D. level in the fields of autophagy, cell death, and/or innate immunity. In a previous study, we found that aspirin triggers cellular autophagy. You can't do it indefinitely but intermittent exposure is great for doing deeper cleanup. Most Cited Articles. Autophagy is published by Landes Bioscience. Background: Breast cancer (BC) is the most common malignancy in women and the second greatest cause of cancer death. More about our metrics . G-Index. Autophagy is a monthly peer-reviewed scientific journal covering all aspects of cell autophagy. Cells is an international, peer-reviewed, open access, journal of cell biology, molecular biology, and biophysics, published semimonthly online by MDPI.The Spanish Society for Biochemistry and Molecular Biology (SEBBM), Signal Transduction Society (STS), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH) and Society for Regenerative Medicine (Russian . Journals for Free (J4F) provides a large database of links to Biology and Life Sciences free scientific journals available on the web. Journal's Graphs. Time‐Efficient Inspiratory Muscle Strength Training Lowers Blood Pressure and Improves Endothelial Function, NO Bioavailability, and Oxidative Stress in Midlife/Older Adults With Above‐Normal Blood Pressure. Wash sections in 1 DPBS/0.1% Tween 20 for 5 min…. Beclin 1 was the first recognized mammalian autophagy gene, and it stimulates the nucleation of the autophagic vesicle ().Beclin 1 is expressed at high levels in colorectal cancer tissues compared with normal tissues ().Beclin 1 expression in vivo markedly suppresses the proliferation of colon cancer cells in xenograft models by inducing apoptosis, and overexpression may . Multivariate Cox regression and LASSO regression were . Impact Factor. Advertisement. Advertisement. Journal of the American Heart Association. The . Autophagy is a catabolic mechanism that recycles cellular components, and the level is dynamically controlled to maintain cell function. More about our metrics . Autophagy is a conserved intracellular pathway that delivers cytoplasmic contents to lysosomes for degradation via double-membrane autophagosomes. Autophagy publishes several types of papers including: Original research (basic science, translational and clinical), reviews (both comprehensive overviews and short puncta), technical papers (toolbox, protocol and resource), commentaries, and articles on science and art.
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